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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4583 | PFI-2 hydrochloride | (R)-PFI-2 hydrochloride,PFI-2 HCl | Histone Methyltransferase |
PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2. | |||
T1987 | PFI-2 | PFI2,PFI 2,(R)-PFI-2 | Histone Methyltransferase |
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. | |||
T6939 | PFI-3 | PFI 3 | Epigenetic Reader Domain |
PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer. | |||
T81175 | SETD7-IN-1 | Histone Methyltransferase | |
SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitory concentration (IC50) of 0.96 ± 0.10 µM [1]. |